‚æ‚Ī‚ą‚ŧ@™Œī‘―Œö’ĘŒĪ‹†Žš‚Ėƒy[ƒW‚ց@>>English Page


–ß‚é
Shinobu Honzawa

y‹ģŽö@–{āV ”E@Shinobu Honzawa

1971”N9ŒŽķ

”ŽŽm(–ōŠw)(“Œ–k‘åŠw)

TEL : 0250-25-5242@FAX : 0250-25-5298
e-mail : honzawa@nupals.ac.jp



Šw—ð
1994”N “Œ‹ž‘åŠw–ōŠw•”ŧ–ō‰ŧŠw‰Č@‘ē‹Æ
1996”N “Œ‹ž‘åŠw‘åŠw‰@–ōŠwŒnŒĪ‹†‰ČCŽm‰Û’ö@C—đ
1999”N “Œ‹ž‘åŠw‘åŠw‰@–ōŠwŒnŒĪ‹†‰Č”ŽŽm‰Û’ö@’†“r‘ÞŠw

E—ð
1999”N`2003”N “Œ–k‘åŠw–ōŠw•”@•Žč
2003”N`2006”N ’é‹ž‘åŠw–ōŠw•”@•Žč
2006”N` VŠƒ–ō‰Č‘åŠw–ōŠw•”@•‹ģŽö


Šwp˜_•ķ
S. Honzawa, N. Takahashi, A. Yamashita, T. Sugiura, M. Kurihara, M. A. Arai, S. Kato, A. Kittaka.
"Synthesis of a 1ƒŋ-C-Methyl Analogue of 25-Hydroxyvitamin D3: Interaction with a Mutant Vitamin D Receptor Arg274Leu"
Tetrahedron 2009, 65, 7153-7145.

S. Honzawa, Y. Yamamoto, A. Yamashita, T. Sugiura, M. Kurihara, M. A. Arai, S. Kato, A. Kittaka.
"The 2ƒŋ-(3-Hydroxypropyl) Group as an Active Motif in Vitamin D3 Analogues as Agonists of the Mutant Vitamin D Receptor (Arg274Leu)"
Bioorg. Med. Chem. 2008, 16, 3002-3024.

N. Saito, S. Honzawa, A. Kittaka.
"Recent Results on A-Ring Modification of 1ƒŋ,25-Dihydroxyvitamin D3: Design and Synthesis of VDR-Agonists and Antagonists with High Biological Activity"
Curr. Top. Med. Chem. 2006, 6, 1273-1288.

S. Honzawa, K. Hirasaka, Y. Yamamoto, S. Peleg, T. Fujishima, M. Kurihara, N. Saito, S. Kishimoto, T. Sugiura, K. Waku, H. Takayama, A. Kittaka.
"Design, Synthesis and Biological Evaluation of Novel 1ƒŋ ,25-Dihydroxyvitamin D3 Analogues Possessing Aromatic Ring on 2ƒŋ-Position"
Tetrahedron, 2005, 61, 11253-11263.

S. Honzawa, Y. Yamamoto, K. Hirasaka, H. Takayama and A. Kittaka
"Synthesis of A-ring Synthon of 2ƒŋ-Substituted Vitamin D3 Analogues Utilizing Grignard Reaction towards Methyl 2,3-Anhydro-4,6-O-benzylidene-ƒŋ-D-mannopyranoside"
Heterocycles, 2003, 61, 327-338.

S. Honzawa, Y. Suhara, K. Nihei, N. Saito, S. Kishimoto, T. Fujishima, M. Kurihara, T. Sugiura, K. Waku, H. Takayama and A. Kittaka
"Concise Synthesis and Biological Activities of 2ƒŋ-Alkyl- and 2ƒŋ-(ƒÖ-Hydroxyalkyl)-20-epi-1ƒŋ,25-dihydroxyvitamin D3"
Bioorg. Med. Chem. Lett., 2003, 13, 3503-3506.

T. Mizutani, S. Honzawa, S. Tosaki and M. Shibasaki
"Total Synthesis of (})-Wortmannin"
Angew. Chem. Int. Ed., 2002, 41, 4680-4682.

S. Honzawa, H. Okubo, S. Anzai, M. Yamaguchi, K. Tsumoto and I. Kumagai
"Chiral Recognition in the Binding of Helicene and Double Strand DNA: Interaction Between Low Molecular Weight Helical Compounds and a Helical Polymer"
Bioorg. Med. Chem., 2002, 10, 3213-3218.

S. Honzawa, H. Okubo, K. Nakamura, S. Anzai, M. Yamaguchi and C. Kabuto
"Folding of Dihelicenetriamines in Water"
Tetrahedron: Asymmetry, 2002, 13, 1043-1052.

S. Honzawa, S. Chiba, H. Okubo and M. Yamaguchi
"One-step Synthesis of Optically Active Cyclic Polyamines Containing Helicene"
Heterocycles, 2002, 57, 1091-1099.

S. Honzawa, S. Ohwada, Y. Morishita, K. Sato, N. Katagiri and M. Yamaguchi
"Synthesis and Hybridization Property of Oligonucleotides Containing Carbocyclic Oxetanocins"
Tetrahedron, 2000, 56, 2615-2627.


〒956-8603 VŠƒŽsH—t‹æ“Œ“‡265-1VŠƒ–ō‰Č‘åŠw–ōŠw•”–ō‰ŧŠw‹ģŽš@TEL & FAX : 0250-25-5241
e-mail : taku@nupals.ac.jp@URL : http://www.taku-lab.com/